SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Ganoderma microsporum immunomodulatory protein acts as a multifunctional broad-spectrum antiviral against SARS-CoV-2 by interfering virus binding to the host cells and spike-mediated cell fusionArticle Published on 2022-11-012022-11-15 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2-expressing cells acute respiratory syndrome alleviate Antiviral binding blocked Broad-spectrum antiviral against SARS-CoV-2 caused Cell Cell fusion cell lines cell-free virus cells characteristic coronavirus Delta determine Diseases downregulation Effect evaluated examined flow cytometry fluorescence microscopy fluorescent Fungal immunomodulatory proteins fusion GMI HEK293T cell host cell immunomodulatory immunoprecipitation in vitro Infection Infectivity ingredient inhibit inhibited inhibitor Interaction investigated less mechanism multifunctional omicron Protein pseudotyped virus reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein SARS-CoV-2 variant spike mutation spike variant spike variants Strains Viral binding. virus were used [DOI] 10.1016/j.biopha.2022.113766 PMC 바로가기
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
PEDOT:PSS in Solution Form Exhibits Strong Potential in Inhibiting SARS-CoV-2 Infection of the Host Cells by Targeting Viruses and Also the Host CellsArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] ACE2-expressing cell acute respiratory syndrome antiviral activity blocked caused Cell cells Combination coronavirus Culture cytotoxicity Effect exhibited form global pandemic high mutation rate inhibitor investigated medium Mutation Potential Prophylactic pseudovirus pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant solution Spike protein Strong targeting the SARS-CoV-2 the spike protein therapeutic transcriptional transcriptomic data Transmission treated Treatment variants virus virus [DOI] 10.1021/acs.biomac.2c00271 PMC 바로가기
GMI, a protein from Ganoderma microsporum, induces ACE2 degradation to alleviate infection of SARS-CoV-2 Spike-pseudotyped virusGanoderma microsporum의 단백질인 GMI는 SARS-CoV-2 Spike-pseudotyped 바이러스의 감염을 완화하기 위해 ACE2 분해를 유도합니다Article Published on 2022-08-012022-09-11 Journal: Phytomedicine : international journal of phytother [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 ACE2 expression activating addition alleviate bafilomycin blocking Cell cell viability cells cloned Cytometry deaths Degradation determined by downregulated dynamin Effect Efficacy examined exhibit expressing flow cytometry fluorescence microscopy fluorescent function Fungal immunomodulatory proteins fungal protein GFP GMI green fluorescent protein HEK293T host cells Human immunomodulatory immunomodulatory functions in vitro induce infecting Infection inhibited inhibiting Interaction lentiviral lung epithelial lung tissue lysosome macrophages mechanism MG132 mice MTT nebulizer not affect overexpressing pandemic Prevent prevention proteasome Protein protein level pseudovirus reduced rescued respiratory responsible S2 domain SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection SARS-CoV-2. Severe acute respiratory syndrome spike Spike protein Therapeutic strategies triggered Type Vaccine viability viral infection virus was determined western blot [DOI] 10.1016/j.phymed.2022.154215 PMC 바로가기 [Article Type] Article
Reduced DMPC and PMPC in lung surfactant promote SARS-CoV-2 infection in obesity폐 계면활성제의 감소된 DMPC 및 PMPC는 비만에서 SARS-CoV-2 감염을 촉진합니다Article Published on 2022-06-012022-09-11 Journal: Metabolism: clinical and experimental [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 expression ACE2 receptor Analysis BALF bind Bronchoalveolar lavage fluid cell-cell fusion assay characterized cholesterol COVID-19 COVID-19 disease COVID-19 pneumonia D614G mutant SARS-CoV-2 Defense DMPC Effect effector cells elevated expressing fat Feeding HEK293T HEK293T cell HEK293T cells High fat diet Hospitalization increased risk Increasing Infection infections inhibited inhibitory effect Inhibitory effects Lipid lipid composition lipid metabolism lipids lung lung surfactant lung tissue Lungs mechanism metabolism mice myristic acid obese obesity outcomes overexpression Phosphatidylcholine Pneumocytes produced promote Protein reduced respiratory virus reversed risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 viral loads SARS-CoV-2. severe COVID-19 disease Severe COVID-19 pneumonia Spike protein surfactant the Spike Triglyceride triglycerides trimyristin Type II pneumocyte type II pneumocytes Vero-E6 cell Vero-E6 cells was performed were used wild type [DOI] 10.1016/j.metabol.2022.155181 PMC 바로가기 [Article Type] Article
Humoral, Cellular and Cytokine Immune Responses Against SARS-CoV-2 Variants in COVID-19 Convalescent and Confirmed Patients With Different Disease Severities다양한 질병 중증도를 가진 COVID-19 회복기 및 확인된 환자의 SARS-CoV-2 변이체에 대한 체액, 세포 및 사이토카인 면역 반응Article Published on 2022-05-172022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] ADE Against Alpha alpha and delta variants Alpha variant Anti-RBD IgG cellular Cellular immune response cellular immunity chemokine chemokines Confirmed convalescent convalescent sera correlation COVID-19 Cytokines delta variant Delta variants disease disease severity ELISA ELISPOT evaluate exhibited fold greater humoral Humoral and cellular immune responses humoral immune response Humoral immunity IgG IL-6 immune immune response immune responses Immunity immunoassays individual Inflammatory mediators inflammatory mediators. IP-10 MCP-1 mediators multiplex neutralization potency Neutralizing activity Omicron variant Omicron variants Patient patients performed pseudovirus pseudovirus infection quantified Raji cells RBD-specific IgG response risk SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant SARS-CoV-2 variants serum severe disease Significant significantly specific antibodies spike-specific antibodies Spike-specific antibody T cell T cells variant virus was measured [DOI] 10.3389/fcimb.2022.862656 PMC 바로가기 [Article Type] Article
Two Opposing Roles of SARS-CoV-2 RBD-Reactive Antibodies in Pre-Pandemic Plasma Samples From Elderly People in ACE2-Mediated Pseudovirus InfectionImmunology Published on 2022-01-112022-10-31 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] acute respiratory syndrome Analysis antibody blood plasma caused coronavirus correlated cross-reactive antibodies cross-reactive antibody domain elderly epitope function functions group had no IgG antibody Korean mechanism neutralization neutralized Neutralizing Neutralizing activity neutralizing effect Novel coronavirus outbreak plasma plasma sample plasma samples positive pre-pandemic samples pseudotype receptor binding domain (RBD) role Sample SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 S1 shown significantly the SARS-CoV-2 viral infection Viral pneumonia virus was used [DOI] 10.3389/fimmu.2021.813240 PMC 바로가기 [Article Type] Immunology
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells423 Published on 2021-12-062022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] A549 ACE2 ACE2 receptors acute respiratory syndrome airways angiotensin-converting enzyme 2 APEX2 bind bypasse C-terminal domain Calu-3 calu-3 cells cathepsin B Cell cells cofactor contribute coronavirus coronavirus disease COVID-19 demonstrated ENhance experiment expression facilitate glycoprotein H1299 Host host cell host receptor human lung cells human tissues Infection inhibitor interact Intervention lung membrane membrane fusion MYH9 N-terminal domain overexpression pan-coronavirus pathway promote protease pseudovirus infection reduce reduced S1-NTD S2 subunit SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 S serine 2 Significance significantly subunit suggested target the SARS-CoV-2 TMPRSS2 transmembrane variety viral entry virus virus entry wild type [DOI] 10.1073/pnas.2111011118 PMC 바로가기 [Article Type] 423
The Effects of Aβ 1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2Article Published on 2021-07-302022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Aβ ACE2 acute respiratory syndrome Alzheimer’s disease Alzheimer’s disease angiotensin-converting enzyme 2 antibody binding Blood C-terminal clearance coronavirus Course COVID-19 Dementia domain Effect elevated Evidence Extracellular high affinity IL-6 Increasing intravenous mechanism prevented progression receptor reducing residue S1 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 spike protein severe coronavirus disease severity spike the SARS-CoV-2 the spike protein trimer viral entry Viral protein [DOI] 10.3390/ijms22158226 PMC 바로가기 [Article Type] Article